If you're using Windows 10 Pro or any other enterprise variant, such as Windows 10 Enterprise or Windows 10 Education, you can use the Local Group Policy Editor to disable Windows Defender from your computer permanently.
- Use the Windows key + R keyboard shortcut to open the Run command.
- Type gpedit.msc and click OK to open the Local Group Policy Editor.
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Browse the following path:
Computer Configuration > Administrative Templates > Windows Components > Windows Defender
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On the right, double-click Turn off Windows Defender.
- Select Enabled to disable Windows Defender.
- Click Apply.
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Click OK.
Original Content from Article Below:
https://www.windowscentral.com/how-permanently-disable-windows-defender-windows-10